Journal of Pharmaceutical and Biomedical Analysis

Synthesis, full chemical characterisation and development of validated methods for the quantification of the components found in the evolved "legal high" NRG-2

Authors

O I G Khreit, C Irving, , E Schmidt, , J A Parkinson, N Nic Daeid, O B Sutcliffe

Abstract

The recent global increase in the abuse of 4'-methylmethcathinone (mephedrone) and related compounds has developed a requirement for full chemical characterisation of these products. This work presents full synthetic and chemical characterisation data for the hydrobromide salts of two mephedrone derivatives: 4'-methyl-N-ethylcathinone (4-MEC) and 4'-methyl-N-benzylcathinone (4-MBC) which have been identified in samples of the "legal high" NRG-2. The first fully validated chromatographic methods for the detection and quantitative analysis of these substances both in their pure form and in the presence of a number of common adulterants used in illicit drug manufacture is also reported.

Publication link

http://www.ncbi.nlm.nih.gov/pubmed/22169465

OIG Khreit, C Irving, E Schmidt, JA Parkinson, N Nic Daeid and OB Sutcliffe (2012) "Synthesis, full chemical characterisation and development of validated methods for the quantification of the components found in the evolved "legal high" NRG-2", Journal of Pharmaceutical and Biomedical Analysis, 61, 122-135.

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